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LGD 4033 , also known as Ligandrol or Anabolicum, is an oral SARM compound that is used to gain muscle mass and prevent muscle wastagein the obese. In this study, a 6-week study with a moderate dose of LDH was implemented to determine safety when taking 5 mg daily in combination with the weight loss diets AIN-7 and ADX-1530 for an 80% bodyweight (BW) and a 70% bodyweight (BW) group, respectively. Sixteen overweight (BMI of 25 to 32 kg/m2) women with a BMI of 36, ligandrol lgd 3303.8 kg/m2 or greater, who received an adequate diet for a BW of 85% BW was enrolled in the study with an initial 4-week, double-blind crossover design with a weight loss of 5%, followed by a 4-week weight maintenance diet with 5% weight loss and then continued for a further 4 weeks, ligandrol lgd 3303. Participants were followed for the weight maintenance and weight loss periods to determine adherence and efficacy. The study protocol and the statistical analysis plan is described in detail in Supplemental Material, which is available at Annals of Internal Medicine online, ligandrol lgd 3303. Methods In this study, the researchers evaluated the safety and efficacy of LDH (30 mg daily) in a 6-week, double-blind, placebo-controlled pilot study with a group of 80 obese (BMI > 30 kg/m2) overweight/obese women on the AIN-7 and ADX-1530 weight loss programs. Of the 12 women that received the treatment group, 5 completed the 6-week study. All individuals treated with LDH reported being satisfied with their weight loss in the study, winstrol 8 weeks. Results In the 60 participants who received LDH, it significantly reduced body fat (p = 0.002 vs. placebo) and total body fat mass (p < 0.03, p = 0.003 vs. placebo), and it suppressed energy intake (p < 0.03 vs. placebo), and it significantly increased insulin sensitivity (p = 0.006 in relation to placebo) and reduced energy intake (p <0.03 vs. placebo) by 0.3 MJ/kg/day; the effect sizes were significant and all were significant after adjustment for total body fat mass, body fat percentage, body composition, physical activity, and insulin sensitivity. Conclusions The LDH therapy demonstrated weight loss without significant negative effects in the study. A study assessing safety of LDH is underway to establish its use as a safe weight management strategy for overweight/obese patients with elevated triglyceride levels. Copyright © 2015 AIN/ACS.
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