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It was developed by the doctors at the Program for Wellness Restoration (PoWeR), who have a formidable history helping patients recover from abnormal hormonal functioning following steroid therapy. One study (4) described a total of 18 patients who underwent the program and reported successful hormonal restoration in all but one case and the result of that restoration was not statistically significant.The PoWiR team believes that the results from this study provide support for the program's effectiveness. They say: "A total of 18 patients with hypothalamic amenorrhea returned to their normal menstrual cycle. One of these 18 was a woman who had undergone a total oophorectomy, with no further recovery of ovarian function. The other 18 patients underwent treatment with OVAO. Seven were free from symptomatic amenorrhea after treatment with OVAO. Nine had amenorrhea within a month and nine within a month and five months, and five were amenorrheic in the first four months and amenorrheic in the latter four months of treatment."The PoWiR team, led by Dr. Karen S. Linnane, M.D., is currently conducting a second phase of the program, in which 22 patients are to undergo ovarian stimulation with OVAO. The PoWiR team estimates that it will cost between $30,000 and $40,000 per patient. The trial is being conducted in collaboration with the Department of Obstetrics and Gynecology, Yale University, New Haven.Dr. Linnane said: "For many women, the goal of the OVAO program is to restore normal hormonal function by decreasing androgen levels.""For ovarian infertility, the goal is to restore fertility so that the woman remains in her first menstrual cycle. The purpose of a clinical trial is to be sure that the intervention works for the majority of patients," she continued. "We wanted patients to come to New Haven to receive this exciting and novel therapy at a very low cost and have the assurance that it will be safe, effective and well-tolerated."Explore further: More women likely to get OVAO treatment, NIH reportsMore information: S.A.H. Linnane et al, Ovarian estrogen administration and estrogen replacement during oophorectomy improves menstrual cycle characteristics and normalizes ovarian function in amenorrheic women, European Journal of Endocrinology (2016). DOI: 10.1027/EEERJ.2016.2560Similar articles: